Zebrafish Hbae1.1 Antibody / Hemoglobin alpha embryonic 1.1 (RZ1228)

Description

Hbae1.1, or hemoglobin alpha embryonic 1.1, is a subunit of embryonic hemoglobin expressed during the early stages of zebrafish development. Hemoglobins are iron binding proteins responsible for oxygen transport in the blood, and in zebrafish, different hemoglobin genes are activated in a stage specific manner to meet the oxygen needs of the developing embryo.

Hbae1.1 is expressed primarily in the intermediate cell mass, which is the site of primitive erythropoiesis in zebrafish embryos. It forms part of the embryonic hemoglobin complex that enables efficient oxygen delivery during rapid cell growth and organ formation. As development progresses, Hbae1.1 expression decreases while adult forms of hemoglobin become dominant.

Due to its specific and transient expression pattern, Hbae1.1 is widely used as a molecular marker for primitive erythroid cells and early blood development in zebrafish. It provides a valuable readout for studying hematopoiesis, gene regulation during red blood cell formation, and the effects of genetic mutations or chemical exposures on early blood cell differentiation.

Zebrafish Hbae1.1 is an important tool in developmental biology, hematology, toxicology, and genetic screening for blood related disorders.

Application Notes

Optimal dilution of the Zebrafish Hbae1.1 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Hbae1.1 recombinant protein (amino acids M1-R143) was used as the immunogen for the Zebrafish Hbae1.1 antibody.

Storage

After reconstitution, the Zebrafish Hbae1.1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.