- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Titration of the XRCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 407-435 from the human protein was used as the immunogen for this XRCC1 antibody.
Aliquot the XRCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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