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Home >> Antibodies >> WASP Antibody

WASP Antibody (R32099)

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  Catalog No Formulation Size Price (USD)  
Image R32099 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
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Western blot testing of 1) rat liver, 2) human placenta, 3) rat spleen, 4) rat pancreas, 5) human HepG2, 6) HeLa, 7) HEPA and 8) 22RV1 lysate with WASP antibody. Expected/observed molecular weight ~53 kDa.
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Western blot testing of 1) rat liver, 2) human placenta, 3) rat spleen, 4) rat pancreas, 5) human HepG2, 6) HeLa, 7) HEPA and 8) 22RV1 lysate with WASP antibody. Expected/observed molecular weight ~53 kDa.
IHC testing of FFPE human lung cancer tissue with WASP antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
IHC testing of frozen human placenta with WASP antibody.
ICC testing of A549 cells with WASP antibody.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P42768
Localization Cytoplasmic
Applications Western blot : 0.1-0.5ug/ml
Immunocytochemistry : 0.5-1ug/ml
IHC (Frozen) : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This WASP antibody is available for research use only.
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  • Applications : WB, ELISA (peptide)
    Reactivity : Human
    Pred. Reactivity : Dog, Mouse, Rat

Description

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Application Notes

Optimal dilution of the WASP antibody should be determined by the researcher.

Immunogen

Amino acids ADEDEAQAFRALVQEKIQKRNQRQSGDR of human WASP were used as the immunogen for the WASP antibody.

Storage

After reconstitution, the WASP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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