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- Tel: 858.663.9055
- Email: info@nsjbio.com
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human. UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes.
Titration of the UBF antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 631-660 from the human protein was used as the immunogen for this UBF1 / UBF antibody.
Aliquot the UBF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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