- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
UACA Antibody [clone AE-5] (V2796)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2796-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 519 | |
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V2796-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 229 | |
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V2796SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | AE-5 |
| Purity | Protein G affinity chromatography |
| UniProt | Q9BZF9 |
| Localization | Nuclear membrane |
| Applications | Flow cytometry : 0.5-1ug/10^6 cells Immunofluorescence : 0.5-1ug/ml Western blot : 0.5-1ug/ml |
| Limitations | This UACA antibody is available for research use only. |
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UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
Optimal dilution of the UACA antibody should be determined by the researcher.
Nuclei of myeloid leukemia biopsy cells were used as the immunogen for the UACA antibody.
Store the UACA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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