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Home >> Antibodies >> Tyrosinase-Related Protein-1 Antibody / TYRP1

Tyrosinase-Related Protein-1 Antibody / TYRP1 [clone TYRP1/8313R] (V5282)

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  Catalog No Formulation Size Price (USD)  
Image V5282-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5282-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5282SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human melanoma tissue with Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human melanoma tissue with Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name TYRP1/8313R
Purity Protein A affinity
UniProt P17643
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This Tyrosinase-Related Protein-1 antibody is available for research use only.
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Description

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Application Notes

Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.

Storage

Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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