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Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Titration of the TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1397-1426 from the human protein was used as the immunogen for this TSC2 antibody.
Aliquot the TSC2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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