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Home >> Antibodies >> TrkC Antibody / NTRK3

TrkC Antibody / NTRK3 [clone NTRK3/7140] (V4396)

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  Catalog No Formulation Size Price (USD)  
Image V4396-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4396-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4396SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human breast cancer with TrkC antibody (clone NTRK3/7140). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human breast cancer with TrkC antibody (clone NTRK3/7140). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human tonsil with TrkC antibody (clone NTRK3/7140). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human brain tissue with TrkC antibody (clone NTRK3/7140). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human salivary gland with TrkC antibody (clone NTRK3/7140). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free TrkC antibody (clone NTRK3/7140) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name NTRK3/7140
Purity Protein A/G affinity
UniProt Q16288
Localization Membrane
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This TrkC antibody is available for research use only.
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Description

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.

Application Notes

Optimal dilution of the TrkC antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the TrkC antibody.

Storage

Aliquot the TrkC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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