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TPX2/p100 is a spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. [UniProt]
Titration of the TPX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A KLH conjugated synthetic peptide from the human protein was used as immunogen for this TPX2 antibody.
Aliquot the TPX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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