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Home >> Antibodies >> TPH1 Antibody / Tryptophan Hydroxylase

TPH1 Antibody / Tryptophan Hydroxylase (RQ4409)

  Catalog No Formulation Size Price (USD)  
Image RQ4409 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) human SGC-7901, 2) rat heart and 3) mouse heart lysate with TPH1 antibody at 0.5ug/ml. Predicted molecular weight ~51 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P17752
Applications Western blot : 0.5-1ug/ml
ELISA : 0.1-0.5ug/ml
Limitations This TPH1 antibody is available for research use only.
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Description

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene. This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Application Notes

Optimal dilution of the TPH1 antibody should be determined by the researcher.

Immunogen

A human partial recombinant protein corresponding to amino acids M1-K111 was used as the immunogen for the TPH1 antibody.

Storage

After reconstitution, the TPH1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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