- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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TPA is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
Titration of the tPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 371-399 from the human protein was used as the immunogen for this tPA antibody.
Aliquot the tPA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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