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- Email: info@nsjbio.com
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Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Titration of the TLE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This TLE1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 187-221 amino acids from the N-terminal region of human TLE1.
Aliquot the TLE1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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