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Home >> Antibodies >> TICAM1 Antibody

TICAM1 Antibody (F52327)

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  Catalog No Formulation Size Price (USD)  
Image F52327-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52327-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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TICAM1 antibody western blot analysis in (1) Ramos cell line and (2) mouse liver tissue lysate. Predicted/observed molecular weight: 76/70-150kDa.
TICAM1 antibody western blot analysis in (1) Ramos cell line and (2) mouse liver tissue lysate. Predicted/observed molecular weight: 76/70-150kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q8IUC6
Applications Western blot : 1:1000
Limitations This TICAM1 antibody is available for research use only.
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Description

Involved in innate immunity against invading pathogens. Adapter used byTLR3andTLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteinsTBK1, TRAF6 andRIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,NF-kappa-Band FADD respectively.

Application Notes

Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.

Storage

Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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