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Home >> Antibodies >> TIA-1 Antibody

TIA-1 Antibody [clone TRIA1-1] (V7235)

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  Catalog No Formulation Size Price (USD)  
Image V7235-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7235-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7235SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of A) HepG2, B) PC3 and C) HeLa cell lysate wiht TIA-1 antibody (clone TRIA1-1). The long and short forms differ by 17 amino acids. Predicted molecular weight: ~43kDa and ~15kDa (granulocyte-associated isoform).
Western blot testing of A) HepG2, B) PC3 and C) HeLa cell lysate wiht TIA-1 antibody (clone TRIA1-1). The long and short forms differ by 17 amino acids. Predicted molecular weight: ~43kDa and ~15kDa (granulocyte-associated isoform).
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name TRIA1-1
Purity Protein G affinity chromatography
Gene ID 7072
Localization Cytoplasmic
Applications Western blot : 1-2ug/ml
Limitations This TIA-1 antibody is available for research use only.
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Description

T-Cell Intracellular Antigen-1 is a cytoplasmic granule-associated protein expressed in lymphocytes processing cytolytic potential. It is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA-1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TIA-1 antibody to be titered up or down for optimal performance.

Immunogen

Human recombinant partial protein (amino acids 279-380) was used as the immunogen for this TIA-1 antibody.

Storage

Store the TIA-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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