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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The thrombospondin proteins (TSP 1-4) compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell surface proteins form complexes of both homo- and heteromultimers. Thrombospondins play a role in development, aggregation of platelets, adhesion and migration of cells, and progression of cells through the growth cycle. Thrombospondin 1 is released from platelets in response to Thrombin stimulation and is a transient component of the extracellular matrix of developing and repairing tissues. Thrombospondin 2 shares a high degree of homology with Thrombospondin 1 and is thought to have overlapping but unique functions. Thrombospondin 3 is a developmentally regulated heparin binding protein. Thrombospondin 4 is neuronally expressed and stimulates neurite outgrowth.
Optimal dilution of the Thrombospondin-1 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Thrombospondin-1 antibody.
Aliquot the Thrombospondin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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