- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TAB3 Antibody (N1201)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
N1201-100UG | 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 429 | |
|
|
N1201-25UG | 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 25 ug | 219 |
|
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Protein A purified antibody |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 257397 |
| Applications | Western blot : 4-8ug/ml |
| Limitations | This TAB3 antibody is available for research use only. |
|
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TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.
Aliquot the TAB3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
TGF-beta-activated kinase 1-binding protein 3, MAP3K7IP3, NAP1
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