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- Tel: 858.663.9055
- Email: info@nsjbio.com
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SUMO2 is a ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. SUMO2 does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. This protein plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS isoforms 1-4.
Titration of the SUMO2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1-30 from the xenla protein was used as the immunogen for this SUMO2 antibody.
Aliquot the SUMO2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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