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Home >> Antibodies >> STING1 Antibody / Transmembrane protein 173 / ERIS / MITA

STING1 Antibody / Transmembrane protein 173 / ERIS / MITA [clone STING1/7435] (V5072)

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  Catalog No Formulation Size Price (USD)  
Image V5072-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5072-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5072SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of human HDLM-2 cell lysate with STING1 antibody (clone STING1/7435). Predicted molecular weight ~42 kDa.
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Western blot testing of human HDLM-2 cell lysate with STING1 antibody (clone STING1/7435). Predicted molecular weight ~42 kDa.
IHC staining of FFPE human tonsil tissue with STING1 antibody (clone STING1/7435). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG, kappa
Clone Name STING1/7435
Purity Protein A/G affinity
UniProt Q86WV6
Localization Cytoplasm
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This STING1 antibody is available for research use only.
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Description

TMEM173 (transmembrane protein 173), also called STING1, MITA and ERIS, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Application Notes

Optimal dilution of the STING1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING1 antibody.

Storage

Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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