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Home >> Antibodies >> STAT3 Antibody

STAT3 Antibody (F47582)

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  Catalog No Formulation Size Price (USD)  
Image F47582-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F47582-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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STAT3 antibody western blot analysis in A375 lysate. Predicted/observed molecular weight ~88kDa.
STAT3 antibody western blot analysis in A375 lysate. Predicted/observed molecular weight ~88kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat, Bovine, Pig
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P40763
Applications Western blot : 1:1000
Limitations This STAT3 antibody is available for research use only.
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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Application Notes

Titration of the STAT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 673-699 from the human protein was used as the immunogen for this STAT3 antibody.

Storage

Aliquot the STAT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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