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- Email: info@nsjbio.com
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This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Titration of the SQSTM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 383-409 from the human protein was used as the immunogen for this SQSTM1 antibody.
Aliquot the SQSTM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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