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Home >> Antibodies >> SLC10A1 Antibody

SLC10A1 Antibody (R30755)

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Image R30755 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of SLC10A1 antibody and Lane 1: rat liver; 2: mouse liver lysate. Expected molecular weight: 38~56 kDa.
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Western blot testing of SLC10A1 antibody and Lane 1: rat liver; 2: mouse liver lysate. Expected molecular weight: 38~56 kDa.
IHC-P: SLC10A1 antibody testing of human liver cancer tissue. HIER: steamed with pH6 citrate buffer.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q14973
Localization Membrane
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 2-5ug/ml
Limitations This SLC10A1 antibody is available for research use only.
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Description

SLC10A1 (Solute carrier family 10 (sodium/bile acid cotransporter family), member 1), also called NTCP or NTCP1, is found in the basolateral membranes of hepatocytes, which is also involved in the reabsorption of bile acids. The SLC10A1 gene is mapped on 14q24.2 and contains 5 exons and spans about 23 kb. Like other sodium/bile acid transporters, SLC10A1 contains an exoplasmic N terminus, an odd number of transmembrane regions, and a cytoplasmic C terminus. Two amphipathic sequences are critical for intramolecular interactions and for proper trafficking of SLC10A1 to the plasma membrane. Injection of in vitro transcribed NTCP cRNA into Xenopus oocytes resulted in the expression of Na(+)-dependent taurocholate uptake. NTCP-mediated taurocholate uptake in oocytes was inhibited by all major bile acid derivatives and by bromosulfophthalein.

Application Notes

Titration of the SLC10A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 141-154 (YSRGIYDGDLKDKV-human) were used as the immunogen for this SLC10A1 antibody.

Storage

The lyophilized SLC10A1 antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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