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Home >> Antibodies >> SHP2 Antibody / PTPN11

SHP2 Antibody / PTPN11 (F53772)

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  Catalog No Formulation Size Price (USD)  
Image F53772-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53772-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of SHP2 antibody and 1) 293, 2) K562 lysate. Predicted molecular weight: ~68kDa.
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Western blot analysis of SHP2 antibody and 1) 293, 2) K562 lysate. Predicted molecular weight: ~68kDa.
IHC analysis of FFPE human hepatocarcinoma stained with SHP2 antibody
Flow cytometric analysis of 293 cells using SHP2 antibody (green) compared to a negative control (blue). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Chicken, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q06124
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Flow Cytometry : 1:10-1:50
Limitations This SHP2 antibody is available for research use only.
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Description

SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Application Notes

Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 526-551 from the human protein was used as the immunogen for this SHP2 antibody.

Storage

Aliquot the SHP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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