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Home >> Antibodies >> SET07 Antibody / KMT5A

SET07 Antibody / KMT5A [clone 43AT551.86] (F40198)

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  Catalog No Formulation Size Price (USD)  
Image F40198-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F40198-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of 293 lysate using SET07 antibody at 1:1000.
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Western blot analysis of 293 lysate using SET07 antibody at 1:1000.
IHC analysis of FFPE human testis tissue stained with SET07 antibody
Immunofluorescence analysis of SET07 antibody and HeLa cells with (bottom) and without (top) PE-conjugated goat anti-mouse lgG secondary.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 43AT551.86
Purity Purified
UniProt Q9NQR1
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Immunofluorescence : 1:10-1:50
Limitations This SET07 antibody is available for research use only.
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Description

SET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]

Application Notes

Titration of the SET07 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This SET07 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07.

Storage

Aliquot the SET07 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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