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Home >> Antibodies >> SERT Antibody / Serotonin Transporter / SLC6A4

SERT Antibody / Serotonin Transporter / SLC6A4 (R32066)

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  Catalog No Formulation Size Price (USD)  
Image R32066 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
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Western blot testing of 1) human HepG2, 2) human Caco-2, 3) human SW620, 4) human COLO-320, 5) human K562 6) human U-2 OS, 7) human U-87 MG, 8) rat heart, 9) mouse heart and 10) mouse SP2/0 cell lysate with SERT antibody. Expected molecular weight: ~70/85-95 kDa (unmodified/glycosylated).
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Western blot testing of 1) human HepG2, 2) human Caco-2, 3) human SW620, 4) human COLO-320, 5) human K562 6) human U-2 OS, 7) human U-87 MG, 8) rat heart, 9) mouse heart and 10) mouse SP2/0 cell lysate with SERT antibody. Expected molecular weight: ~70/85-95 kDa (unmodified/glycosylated).
IHC testing of FFPE human breast cancer tissue with SERT antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
IHC testing of FFPE rat brain with SERT antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P31645
Localization Cell membrane
Applications Western blot : 0.1-0.5ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This SERT antibody is available for research use only.
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Description

SLC6A4 (Solute carrier family 6, member 4), also known as SERT (serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium: neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Application Notes

Optimal dilution of the SERT antibody should be determined by the researcher.

Immunogen

Amino acids DDTRHSIPATTTTLVAELHQGERETWGKK of human SLC6A4/SERT were used as the immunogen for the SERT antibody.

Storage

After reconstitution, the SERT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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