- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SDHB Antibody (F47686)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F47686-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F47686-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Bovine, Mouse, Pig |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P21912 |
| Applications | Western blot : 1:1000 |
| Limitations | This SDHB antibody is available for research use only. |
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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Titration of the SDHB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 205-234 from the human protein was used as the immunogen for this SDHB antibody.
Aliquot the SDHB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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