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Home >> Antibodies >> SDHA Antibody

SDHA Antibody [clone SDHA/7491] (V5081)

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  Catalog No Formulation Size Price (USD)  
Image V5081-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5081-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5081SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human colon carcinoma tissue with SDHA antibody (clone SDHA/7491). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human colon carcinoma tissue with SDHA antibody (clone SDHA/7491). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free SDHA antibody (clone SDHA/7491) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2, kappa
Clone Name SDHA/7491
Purity Protein A/G affinity
UniProt P31040
Localization Cytoplasm (Mitochondria)
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This SDHA antibody is available for research use only.
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Description

In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

Application Notes

Optimal dilution of the SDHA antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 450-650) from the human protein was used as the immunogen for the SDHA antibody.

Storage

Aliquot the SDHA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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