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Home >> Antibodies >> ROS1 Antibody

ROS1 Antibody [clone ROS1/8268R] (V5181)

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  Catalog No Formulation Size Price (USD)  
Image V5181-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5181-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5181SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human epididymis tissue with ROS1 antibody (clone ROS1/8268R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human epididymis tissue with ROS1 antibody (clone ROS1/8268R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free ROS1 antibody (clone ROS1/8268R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name ROS1/8268R
Purity Protein A/G affinity
UniProt P08922
Localization Cell surface, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This ROS1 antibody is available for research use only.
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Description

ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium. The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma. Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2.

Application Notes

Optimal dilution of the ROS1 antibody should be determined by the researcher.

Immunogen

A recombinant fragment corresponding to the cytoplasmic domain of human ROS1 protein was used as the immunogen for the ROS1 antibody.

Storage

Aliquot the ROS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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