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Home >> Antibodies >> Recombinant Kappa Antibody

Recombinant Kappa Antibody [clone rKLC264] (V3606)

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  Catalog No Formulation Size Price (USD)  
Image V3606-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 539
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V3606-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 249
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V3606SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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V3606IHC-7ML Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* 7 ml 539
Microvalidated Recmousemono
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IHC testing of FFPE human tonsil tissue with recombinant Kappa antibody (clone rKLC264). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.
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IHC testing of FFPE human tonsil tissue with recombinant Kappa antibody (clone rKLC264). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.
SDS-PAGE analysis of purified, BSA-free recombinant Kappa antibody (clone rKLC264) as confirmation of integrity and purity.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using recombinant Kappa antibody (clone rKLC264). These results demonstrate the foremost specificity of the rKLC264 mAb.
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rKLC264
Purity Protein G affinity chromatography
UniProt P01601 , P01834
Localization Cell Surface, cytoplasmic and secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This recombinant Kappa antibody is available for research use only.
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Description

Recombinant Kappa antibody is a dependable reagent for detecting immunoglobulin kappa light chains, one of the two types of antibody light chains that pair with heavy chains to form intact immunoglobulins. Kappa chains, encoded by the IGKC gene, are expressed in a majority of human antibodies and play a central role in antigen recognition. The ability to distinguish kappa from lambda light chains is critical in immunology, hematology, and pathology research.

Antibody molecules consist of two heavy chains and two light chains, with light chains classified as either kappa or lambda. The variable domain of the kappa chain contributes directly to antigen binding, while its constant domain helps stabilize antibody structure. In clinical settings, altered kappa to lambda ratios can indicate plasma cell disorders, making kappa chain detection highly valuable.

The Recombinant Kappa antibody clone rKLC264 provides specific and reproducible recognition of kappa light chains. Recombinant production ensures uniformity across lots, reducing variability between experiments. Clone rKLC264 has been applied to studies of immunoglobulin diversity, B cell biology, and plasma cell disorders. Its reliability makes it suitable for both basic research and diagnostic applications.

Research using clone rKLC264 has supported investigations into multiple myeloma, lymphoma, and immune regulation. Monitoring kappa light chain expression provides insight into antibody repertoire and disease progression. The antibody also contributes to work on therapeutic antibody development, where understanding light chain usage is critical.

NSJ Bioreagents offers this Recombinant Kappa antibody to enable high quality research in immunology and hematology. The protein is also known as IGKC antibody, immunoglobulin kappa chain antibody, kappa immunoglobulin protein antibody, and antibody kappa light chain antibody, reflecting the varied terms found in scientific literature.

Application Notes

The optimal dilution of the recombinant Kappa antibody for each application should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Recombinant human Ig kappa chain was used as the immunogen for this recombinant Kappa antibody.

Storage

Store the recombinant Kappa antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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   3.   View all human protein microarray validated antibodies

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