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Home >> Antibodies >> Recombinant ESR1 Antibody / Estrogen Receptor alpha

Recombinant ESR1 Antibody / Estrogen Receptor alpha [clone ESR1/6983R] (V9393)

  Catalog No Formulation Size Price (USD)  
Image V9393-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9393-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9393SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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Western blot testing of human MCF-7 cell lysate using recombinant ESR1 antibody (clone ESR1/6983R).
IHC staining of FFPE human breast carcinoma tissue with recombinant ESR1 antibody (clone ESR1/6983R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name ESR1/6983R
Purity Protein A/G affinity
UniProt P03372
Localization Nucleus
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant ESR1 antibody is available for research use only.
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Description

Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas.

Application Notes

Optimal dilution of the recombinant ESR1 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 495-595 was used as the immunogen for the recombinant ESR1 antibody.

Storage

Aliquot the recombinant ESR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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