- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
RANTES Antibody / CCL5 [clone ADHH-3] (RQ5403)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5403 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | ADHH-3 |
| Purity | Affinity purified |
| UniProt | P13501 |
| Applications | Western blot : 1:1000-1:5000 |
| Limitations | This RANTES antibody is available for research use only. |
|
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The CCL5 gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [RefSeq]
Optimal dilution of the RANTES antibody should be determined by the researcher.
A synthetic peptide specific to human RANTES / CCL5 was used as the immunogen for the RANTES antibody.
Store the RANTES antibody at -20oC.
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