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Home >> Antibodies >> PRKAR1A Antibody

PRKAR1A Antibody (R32679)

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  Catalog No Formulation Size Price (USD)  
Image R32679 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat thymus, 2) human HepG2 and 3) human MCF7 lysate with PRKAR1A antibody at 0.5ug/ml. Predicted molecular weight ~48 kDa.
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Western blot testing of 1) rat thymus, 2) human HepG2 and 3) human MCF7 lysate with PRKAR1A antibody at 0.5ug/ml. Predicted molecular weight ~48 kDa.
IHC testing of FFPE human lung cancer tissue with PRKAR1A antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE human intestinal cancer tissue with PRKAR1A antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE rat testis tissue with PRKAR1A antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
UniProt P10644
Localization Cytoplasmic, membranous
Applications Western Blot : 0.5-1ug/ml
IHC (FFPE) : 1-2ug/ml
Limitations This PRKAR1A antibody is available for research use only.
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Description

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. This protein encoded by this gene was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Application Notes

Optimal dilution of the PRKAR1A antibody should be determined by the researcher.

Immunogen

Amino acids E2-E81 from the human protein were used as the immunogen for the PRKAR1A antibody.

Storage

After reconstitution, the PRKAR1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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