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Home >> Antibodies >> PR Antibody / Isoform A & B

PR Antibody / Isoform A & B [clone 312CT8.2.1.6] (F53580)

  Catalog No Formulation Size Price (USD)  
Image F53580-0.1ML In ascites with 0.09% sodium azide 0.1 ml 399
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PR antibody western blot analysis in SK-BR-3 lysate. Expected molecular weight: 82-94 kDa (isoform A) and 99-120 kDa (isoform B).
Availability 1-3 business days
Species Reactivity Human
Format Ascites
Clonality Monoclonal (mouse origin)
Isotype Mouse IgM
Clone Name 312CT8.2.1.6
Purity Ascites
UniProt P06401
Applications Western blot : 1:100-1:3200
Limitations This PR antibody is available for research use only.
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Description

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.

Application Notes

Titration of the PR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 349-377 from the human protein was used as the immunogen for this PR antibody.

Storage

Aliquot the PR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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