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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
Titration of the PPP3CC antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 18-47 from the human protein was used as the immunogen for this PPP3CC antibody.
Aliquot the PPP3CC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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