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Home >> Antibodies >> PIN1 Antibody

PIN1 Antibody (R31729)

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Image R31729 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human Caco-2 cells with PIN1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PIN1 antibody.
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Flow cytometry testing of human Caco-2 cells with PIN1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PIN1 antibody.
Western blot testing of 1) human HeLa, 2) human 293T, 3) human MCF7, 4) monkey COS-7, 5) rat brain, 6) rat liver, 7) mouse brain and 8) mouse liver tissue lysate with PIN1 antibody. Predicted molecular weight ~18 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat, Monkey
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
Gene ID 5300
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This PIN1 antibody is available for research use only.
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Description

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It binds to a subset of proteins and thus plays a role as a post-phosphorylation control in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, up-regulation of may be implicated in certain cancers, and the down-regulation may be implicated in Alzheimers disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. It also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the PIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 1-163) was used as the immunogen for this PIN1 antibody.

Storage

After reconstitution, the PIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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