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- Email: info@nsjbio.com
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In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Titration of the phospho-TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT417 of rat TSC1.
Aliquot the phospho-TSC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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