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Home >> Antibodies >> Phospho-NANOG Antibody (pS285)

Phospho-NANOG Antibody (pS285) (F48602)

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  Catalog No Formulation Size Price (USD)  
Image F48602-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48602-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Dot blot analysis of phospho-NANOG antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Dot blot analysis of phospho-NANOG antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9H9S0
Applications Dot blot : 1:500
Limitations This phospho-NANOG antibody is available for research use only.
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Description

NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.

Application Notes

Titration of the phospho-NANOG antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This phospho-NANOG antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS285 of human Nanog.

Storage

Aliquot the phospho-NANOG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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