- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-IRE1 Antibody (pS724) [clone EGH-5] (RQ4781)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ4781 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | EGH-5 |
| Purity | Affinity purified |
| UniProt | O75460 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This phospho-IRE1 antibody is available for research use only. |
|
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IRE1 is a serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the ER luminal domain is maintained in its inactive monomeric state by binding to the ER chaperone HSPA5/BiP. Accumulation of misfolded protein in the ER causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. [UniProt]
Optimal dilution of the phospho-IRE1 antibody should be determined by the researcher.
A synthetic peptide specific to human IRE1 / ERN1 (surrounding pS724) was used as the immunogen for the phospho-IRE1 antibody.
Store the phospho-IRE1 antibody at -20oC.
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