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Home >> Antibodies >> Phospho-ErbB2 Antibody (pY1140)

Phospho-ErbB2 Antibody (pY1140) (F48697)

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  Catalog No Formulation Size Price (USD)  
Image F48697-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48697-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from A431 cell line, untreated or treated with EGF (100ng/ml), using phospho-ErbB2 antibody.
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Western blot analysis of lysate from A431 cell line, untreated or treated with EGF (100ng/ml), using phospho-ErbB2 antibody.
Western blot analysis of extracts from SK-BR-3 cell, untreated or treated with NRG, using phospho-ErbB2 (left) or nonphos Ab (right).
Dot blot analysis of phospho-ErbB2 antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P70424
Applications Western blot : 1:1000
Dot blot : 1:500
Limitations This phospho-ErbB2 antibody is available for research use only.
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Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Application Notes

Titration of the phospho-ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This phospho-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1140 of mouse HER2/ERBB2.

Storage

Aliquot the phospho-ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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