- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-c-Raf Antibody (pS621) [clone IOF-18] (RQ5031)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5031 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | IOF-18 |
| Purity | Affinity purified |
| UniProt | P04049 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This phospho-c-Raf antibody is available for research use only. |
|
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Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). [UniProt]
Optimal dilution of the phospho-c-Raf antibody should be determined by the researcher.
A synthetic peptide specific to human Raf1 (surrounding pS621) was used as the immunogen for the phospho-c-Raf antibody.
Store the phospho-c-Raf antibody at -20oC.
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