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The ATF2 gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. [RefSeq]
Optimal dilution of the phospho-ATF2 antibody (pT71) should be determined by the researcher.
A synthetic peptide specific to human ATF2 (surrounding pT71) was used as the immunogen for the phospho-ATF2 antibody.
Store the phospho-ATF2 antibody (pT71) at -20oC.
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