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Home >> Antibodies >> PAX8 Antibody Cocktail

PAX8 Antibody Cocktail [clone PAX8/1491 + PAX8/1492] (V3414)

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  Catalog No Formulation Size Price (USD)  
Image V3414-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3414-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3414SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human renal cell carcinoma with PAX8 antibody cocktail (clone PAX8-1491 + PAX8/1492). Required HIER: boil tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 minutes.
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IHC testing of FFPE human renal cell carcinoma with PAX8 antibody cocktail (clone PAX8-1491 + PAX8/1492). Required HIER: boil tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 minutes.
Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX8 antibody cocktail (clone PAX8/1491 + PAX8/1492). Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX8 can also be observed at ~62 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b + Mouse IgG2a
Clone Name PAX8/1491 + PAX8/1492
Purity Protein G affinity chromatography
UniProt Q06710
Localization Nuclear, cytoplasmic
Applications Flow cytometry : 0.5-1ug/10^6 cells
Immunofluorescence : 1-2ug/ml
Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This PAX8 antibody cocktail is available for research use only.
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Description

PAX8 is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

Application Notes

Optimal dilution of the PAX-8 antibody cocktail should be determined by the researcher.

Immunogen

A human recombinant fragment (aa 60-261) was used as the immunogen for the PAX8 antibody cocktail.

Storage

Store the PAX8 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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