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Home >> Antibodies >> PAX3 Antibody / Paired box 3

PAX3 Antibody / Paired box 3 [clone PAX3/4700] (V4956)

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  Catalog No Formulation Size Price (USD)  
Image V4956-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4956-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4956SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free PAX3 antibody (clone PAX3/4700) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free PAX3 antibody (clone PAX3/4700) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name PAX3/4700
Purity Protein A/G affinity
UniProt P23760
Localization Nucleus
Applications ELISA (Order BSA-free format for coating) :
Limitations This PAX3 antibody is available for research use only.
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Description

Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the PAX3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcription factors, are responsible for Waardenburg syndrome II (WSII) and WSI/WSIII, respectively.

Application Notes

Optimal dilution of the PAX3 antibody should be determined by the researcher.

Immunogen

A synthetic peptide from the C-terminus region of the quail protein was used as the immunogen for the PAX3 antibody.

Storage

Aliquot the PAX3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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