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Home >> Antibodies >> PAX-8 Antibody

PAX-8 Antibody [clone PAX8/1491] (V3412)

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  Catalog No Formulation Size Price (USD)  
Image V3412-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3412-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3412SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX-8 antibody (clone PAX8/1491). Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX-8 can also be observed at ~62 kDa.
Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX-8 antibody (clone PAX8/1491). Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX-8 can also be observed at ~62 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name PAX8/1491
Purity Protein G affinity chromatography
UniProt Q06710
Localization Nuclear, cytoplasmic
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This PAX-8 antibody is available for research use only.
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Description

PAX-8 is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

Application Notes

Optimal dilution of the PAX-8 antibody should be determined by the researcher.

Immunogen

A human recombinant fragment (aa 60-261) was used as the immunogen for the PAX-8 antibody.

Storage

Store the PAX-8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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