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Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). [UniProt]
Titration of the PAX-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 352-380 from the human protein was used as the immunogen for this PAX-6 antibody.
Aliquot the PAX-6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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