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- Email: info@nsjbio.com
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Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin 6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5.
Optimal dilution of the Pan-Cadherin antibody should be determined by the researcher.
A recombinant fragment of human C-terminal of Pan-Cadherin was used as the immunogen for the Pan-Cadherin antibody.
Aliquot the Pan-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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