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Home >> Antibodies >> p-PARP Antibody (pS372)

p-PARP Antibody (pS372) (F48728)

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  Catalog No Formulation Size Price (USD)  
Image F48728-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48728-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Dot blot analysis of p-PARP antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Dot blot analysis of p-PARP antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P09874
Applications Dot blot : 1:500
Limitations This p-PARP antibody is available for research use only.
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Description

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Application Notes

Titration of the p-PARP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This p-PARP antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS372 of human PARP1.

Storage

Aliquot the p-PARP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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