- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
OTUD5 (ovarian tumor domain-containing 5), also called DUBA (Deubiquitinating enzyme A), is a product of the OTUD5 gene, and a suppressor of the innate immune response via its deubiquitinating activity. The Innate immune systems provide immediate but short-lived defense against infection identified by PRRs, or pattern recognition receptors. OTUD5 cleaves the lysine-63-linked polyubiquitin chains of TRAF3, causing it to dissociate from TBK1, thereby failing to stimulate IFN type 1 production and leading to a suppressed innate immune response.
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
A recombinant protein fragment from the C-terminal region of human OTUD5 was used as the immunogen for this antibody.
Aliquot the antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
DUBA, Deubiquitinating enzyme A, OTU domain containing protein 5
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