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- Tel: 858.663.9055
- Email: info@nsjbio.com
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This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Titration of the OKT4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This monoclonal OKT4 antibody was produced from a mouse immunized with human peripheral T cells.
Aliquot the OKT4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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