- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Nix Antibody / BNIP3L [clone ABIB-2] (RQ4749)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ4749 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | ABIB-2 |
| Purity | Affinity purified |
| UniProt | O60238 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This Nix antibody is available for research use only. |
|
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'BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like' (BNIP3L), also called NIP3-like protein X (Nix) induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. [UniProt]
Optimal dilution of the Nix antibody should be determined by the researcher.
A synthetic peptide specific to human Nix / BNIP3L was used as the immunogen for the Nix antibody.
Store the Nix antibody at -20oC.
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