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Home >> Antibodies >> NCAPH2 Antibody

NCAPH2 Antibody (F40112)

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  Catalog No Formulation Size Price (USD)  
Image F40112-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F40112-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of NCAPH2 antibody and HepG2 lysate.
Western blot analysis of NCAPH2 antibody and HepG2 lysate.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q6IBW4
Applications Western blot : 1:1000
Limitations This NCAPH2 antibody is available for research use only.
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Description

Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.

Application Notes

Titration of the NCAPH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 198-227 from the human protein was used as the immunogen for this NCAPH2 antibody.

Storage

Aliquot the NCAPH2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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